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2021 Mercedes-Benz E350 Problems

Owner-reported complaints filed with NHTSA, grouped by component

Data refreshed

Owner complaintsComplaints are reports submitted to NHTSA by owners and drivers. NHTSA does not verify most reports before publishing them, and a complaint does not establish that a defect exists. Volume is influenced by how many of a vehicle were sold, how long it has been on the road, and how much attention an issue has received.
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Latest Aug 8, 2026
Components namedHow many of our component categories appear on at least one report for this model year. One report can name several.
6
Crash or fire reportedComplaints whose submitter recorded that a crash or a fire occurred. These are the reporter's own answers on the NHTSA form, not verified findings.
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What this page shows

Everything below is an owner-reported complaint submitted to NHTSA about the 2021 Mercedes-Benz E350, grouped by the component NHTSA recorded on the report. These are not confirmed defects, and they are not recalls. NHTSA does not verify most reports before publishing them, and a category with more reports in it is not evidence that a part is defective.

Complaints are reports submitted by owners and drivers to NHTSA. They are not verified and do not establish that a defect exists.

Reports by component

Ranked by how many owner reports name each component category

  • Electrical422.2%
  • Engine422.2%
  • Driver assistance316.7%
  • Fuel system316.7%
  • Powertrain (other)316.7%
  • Brakes15.6%

Percentages are of component mentions. A single complaint can name more than one component, so these do not sum to the total complaint count.

Each component in detail

What the reports in each category say, in the owners' own words

Electrical

Reports naming the electrical system — wiring, battery, charging, control modules, infotainment and electrical accessories.

4
reports

From owner reports, verbatim

Vehicle: 2021 Mercedes-Benz E350 Sedan (W213) VIN: [XXX] While operating the vehicle, the diagnostic system displayed the fault code P240200 related to the Evaporative Emission Control System (EVAP). The warning message indicated a “positive short circuit” in the fuel vapor leak diagnosis pump control circuit. The malfunction appears to involve the EVAP diagnostic module and/or associated electrical wiring near the fuel system. The affected component may be available for inspection upon request. The issue raises safety concerns because the fault involves an electrical short circuit associated with the fuel vapor control system. Potential risks may include electrical overheating, malfunction of the fuel vapor management system, fuel vapor leakage, emissions-related failures, or unexpected vehicle operating issues. Prior to the incident, warning messages appeared on the vehicle diagnostic display. The fault code was identified using the vehicle’s onboard diagnostic system. No collision or fire occurred at this time. The problem has not yet been fully repaired, but preliminary assessment suggests a possible failure of the EVAP leak detection pump, control module, wiring harness, connector, or related electrical components. The condition may be reproducible because the warning message remains active. The vehicle has not yet been inspected by the manufacturer or insurance representatives. Dealer inspection is planned. UNKNOWN whether this condition is currently associated with an official recall or service campaign for this VIN. This vehicle was originally purchased in the United States and is currently located outside the [XXX] . INFORMATION REDACTED PURSUANT TO THE FREEDOM OF INFORMATION ACT (FOIA), 5 U.S.C. 552(B)(6)

NHTSA ID 11736678 · filed May 8, 2026

1) Rear view camera sometimes working, some times not working. (Message reads “system inoperative “ 2) Forward view camera also affected. 3) display shown “12V battery low in battery “ 4) Not long ago, just had vehicle suddenly vibrating vigorously while backing up from parking and during driving. Gas paddle not responding when stepping down, ( vehicle was then towed to dealer and they updated some kind of electrical thing)

NHTSA ID 11649636 · filed Mar 21, 2025

Too few reports in this category for a page of its own — they appear in the full complaint list.

Engine

Reports naming the engine itself — including stalling, misfires, oil consumption, cooling and internal engine components.

4
reports

From owner reports, verbatim

Engine keeps having a misfire that Mercedes put a TSB out for and once the misfire happen I cause the vehicle to go in a limp mode which causes the vehicle to loose power happened to me in the freeway. The car had 54K miles and Mercedes refused to repair the issue as the engine part failure isn’t common.

NHTSA ID 11707258 · filed Dec 27, 2025

My 2021 Mercedes-Benz E350 (VIN [XXX] ) developed a serious engine issue involving cylinder misfire and check engine light. The dealer diagnosed it as a leaking exhaust valve on cylinder 4, related to TSB LI01.30-P-072328, which documents valve seat wear in M260 engines. This is a known defect acknowledged by Mercedes in technical bulletins, and other customers in the U.S. have received warranty extensions or goodwill coverage. I was denied coverage even though this is a manufacturer defect that can lead to misfire, power loss, and potential stalling, posing a safety risk on the road. Mercedes-Benz USA refuses to cover the repair (~$7,600+), even though it relates to a factory-documented problem. I’m requesting that NHTSA investigate this engine defect, as it may qualify for a safety recall or mandatory extended warranty coverage. INFORMATION REDACTED PURSUANT TO THE FREEDOM OF INFORMATION ACT (FOIA), 5 U.S.C. 552(B)(6)

NHTSA ID 11673376 · filed Jul 14, 2025

Too few reports in this category for a page of its own — they appear in the full complaint list.

Driver assistance

Reports naming forward-collision avoidance, lane keeping, back-over prevention, cruise control and related electronic driver-assistance systems.

3
reports

From owner reports, verbatim

1) Rear view camera sometimes working, some times not working. (Message reads “system inoperative “ 2) Forward view camera also affected. 3) display shown “12V battery low in battery “ 4) Not long ago, just had vehicle suddenly vibrating vigorously while backing up from parking and during driving. Gas paddle not responding when stepping down, ( vehicle was then towed to dealer and they updated some kind of electrical thing)

NHTSA ID 11649636 · filed Mar 21, 2025

I was parking and the 360 view sensor did not come up. When I tried to back out and move forward again, I realized the back up camera would not come on. I turned the car on and off and then tried again to reverse to engage the camera but was instead given a message that says system inoperative.

NHTSA ID 11589422 · filed May 18, 2024

Too few reports in this category for a page of its own — they appear in the full complaint list.

Fuel system

Reports naming fuel storage or delivery — tanks, pumps, lines, injectors and fuel leaks.

3
reports

From owner reports, verbatim

Vehicle: 2021 Mercedes-Benz E350 Sedan (W213) VIN: [XXX] While operating the vehicle, the diagnostic system displayed the fault code P240200 related to the Evaporative Emission Control System (EVAP). The warning message indicated a “positive short circuit” in the fuel vapor leak diagnosis pump control circuit. The malfunction appears to involve the EVAP diagnostic module and/or associated electrical wiring near the fuel system. The affected component may be available for inspection upon request. The issue raises safety concerns because the fault involves an electrical short circuit associated with the fuel vapor control system. Potential risks may include electrical overheating, malfunction of the fuel vapor management system, fuel vapor leakage, emissions-related failures, or unexpected vehicle operating issues. Prior to the incident, warning messages appeared on the vehicle diagnostic display. The fault code was identified using the vehicle’s onboard diagnostic system. No collision or fire occurred at this time. The problem has not yet been fully repaired, but preliminary assessment suggests a possible failure of the EVAP leak detection pump, control module, wiring harness, connector, or related electrical components. The condition may be reproducible because the warning message remains active. The vehicle has not yet been inspected by the manufacturer or insurance representatives. Dealer inspection is planned. UNKNOWN whether this condition is currently associated with an official recall or service campaign for this VIN. This vehicle was originally purchased in the United States and is currently located outside the [XXX] . INFORMATION REDACTED PURSUANT TO THE FREEDOM OF INFORMATION ACT (FOIA), 5 U.S.C. 552(B)(6)

NHTSA ID 11736678 · filed May 8, 2026

The engine is misfiring and not powering correctly during driving. Car is failing to take off and today almost caused an accident due to the car would not pull off from the traffic light with oncoming traffic due to loss of power. Safety was at risk due to an accident was almost caused due to car not moving in on coming traffic Dealership is citing that is needs to have a cylinder replaced but will not tell me why it needs to be replaced, why this has happened or what could have been done pre maintenance to avoid this issue Check engine light came on Dealer has been contacted, and was told this is a common issue for this to happen to newer cars, but will not fix the issue and extended warranty will not cover due to this is a manufacturer issue

NHTSA ID 11571057 · filed Feb 9, 2024

Too few reports in this category for a page of its own — they appear in the full complaint list.

Powertrain (other)

Powertrain reports that are not specifically the engine or transmission — driveshafts, axles, transfer cases and differentials.

3
reports

From owner reports, verbatim

Engine misfires, lower engine power, and a lit check engine/Malfunction Indicator Lamp. Mercedes-Benz issued an Emission Service Campaign (No. 2021070006, internal code 21P1590208) to replace out-of-spec ignition coils on 657 vehicles from model year 2021, including the E-Class. My VIN was not included in the recall campaign but my vehicle is experiencing these exact symptoms as referenced in the first sentence. My vehicle has 48,000 miles.

NHTSA ID 11755689 · filed Aug 8, 2026

With the car only have about 15,000 miles the transmission has failed . I have seen there have been recalls of other models with similar complaints of transmission failure .

NHTSA ID 11708688 · filed Jan 4, 2026

Too few reports in this category for a page of its own — they appear in the full complaint list.

Brakes

Reports naming service brakes, the antilock braking system, brake hoses, master cylinders or the parking brake.

1
report

From owner reports, verbatim

The contact owns a 2021 Mercedes-Benz E350. The contact stated that while parking the vehicle the emergency brake independently seized. The contact stated that the vehicle abruptly stopped. The vehicle would not drive forward or backward. The contact contacted the dealer and a service technician was dispatched to the location. The service technician connected the vehicle to the diagnostic equipment. The contact was advised that the vehicle was not safe to drive. The vehicle was towed to the dealer where it was diagnosed with a failed brake caliber voltage malfunction and the brake caliber voltage needed to be replaced. The vehicle was repaired. The manufacturer was made aware of the failure. The failure mileage was approximately 24,001.

NHTSA ID 11578960 · filed Mar 22, 2024

Too few reports in this category for a page of its own — they appear in the full complaint list.

Higher-selling and older vehicles accumulate more reports. Counts are not failure rates and are not directly comparable between vehicles that sold in very different numbers.

Elsewhere on this vehicle

Data sources

Data on this page last refreshed .