2021 Mercedes-Benz E350

Engine misfires, lower engine power, and a lit check engine/Malfunction Indicator Lamp. Mercedes-Benz issued an Emission Service Campaign (No. 2021070006, internal code 21P1590208) to replace out-of-spec ignition coils on 657 vehicles from model year 2021, including the E-Class. My VIN was not included in the recall campaign but my vehicle is experiencing these exact symptoms as referenced in the first sentence. My vehicle has 48,000 miles.

NHTSA ID

11755689

Incident

Aug 4, 2026

Vehicle: 2021 Mercedes-Benz E350 Sedan (W213) VIN: [XXX] While operating the vehicle, the diagnostic system displayed the fault code P240200 related to the Evaporative Emission Control System (EVAP). The warning message indicated a “positive short circuit” in the fuel vapor leak diagnosis pump control circuit. The malfunction appears to involve the EVAP diagnostic module and/or associated electrical wiring near the fuel system. The affected component may be available for inspection upon request. The issue raises safety concerns because the fault involves an electrical short circuit associated with the fuel vapor control system. Potential risks may include electrical overheating, malfunction of the fuel vapor management system, fuel vapor leakage, emissions-related failures, or unexpected vehicle operating issues. Prior to the incident, warning messages appeared on the vehicle diagnostic display. The fault code was identified using the vehicle’s onboard diagnostic system. No collision or fire occurred at this time. The problem has not yet been fully repaired, but preliminary assessment suggests a possible failure of the EVAP leak detection pump, control module, wiring harness, connector, or related electrical components. The condition may be reproducible because the warning message remains active. The vehicle has not yet been inspected by the manufacturer or insurance representatives. Dealer inspection is planned. UNKNOWN whether this condition is currently associated with an official recall or service campaign for this VIN. This vehicle was originally purchased in the United States and is currently located outside the [XXX] . INFORMATION REDACTED PURSUANT TO THE FREEDOM OF INFORMATION ACT (FOIA), 5 U.S.C. 552(B)(6)

NHTSA ID

11736678

Incident

May 2, 2026

With the car only have about 15,000 miles the transmission has failed . I have seen there have been recalls of other models with similar complaints of transmission failure .

NHTSA ID

11708688

Incident

Dec 25, 2025

Engine keeps having a misfire that Mercedes put a TSB out for and once the misfire happen I cause the vehicle to go in a limp mode which causes the vehicle to loose power happened to me in the freeway. The car had 54K miles and Mercedes refused to repair the issue as the engine part failure isn’t common.

NHTSA ID

11707258

Incident

Dec 2, 2025

My 2021 Mercedes-Benz E350 (VIN [XXX] ) developed a serious engine issue involving cylinder misfire and check engine light. The dealer diagnosed it as a leaking exhaust valve on cylinder 4, related to TSB LI01.30-P-072328, which documents valve seat wear in M260 engines. This is a known defect acknowledged by Mercedes in technical bulletins, and other customers in the U.S. have received warranty extensions or goodwill coverage. I was denied coverage even though this is a manufacturer defect that can lead to misfire, power loss, and potential stalling, posing a safety risk on the road. Mercedes-Benz USA refuses to cover the repair (~$7,600+), even though it relates to a factory-documented problem. I’m requesting that NHTSA investigate this engine defect, as it may qualify for a safety recall or mandatory extended warranty coverage. INFORMATION REDACTED PURSUANT TO THE FREEDOM OF INFORMATION ACT (FOIA), 5 U.S.C. 552(B)(6)

NHTSA ID

11673376

Incident

Jul 1, 2025

The Mercedes E350, with 22,000 miles suffered a catastrophic transmission failure while driving on the highway. I managed to exit the highway but the car could not be moved and left me stranded.

NHTSA ID

11672435

Incident

Jul 9, 2025

1) Rear view camera sometimes working, some times not working. (Message reads “system inoperative “ 2) Forward view camera also affected. 3) display shown “12V battery low in battery “ 4) Not long ago, just had vehicle suddenly vibrating vigorously while backing up from parking and during driving. Gas paddle not responding when stepping down, ( vehicle was then towed to dealer and they updated some kind of electrical thing)

NHTSA ID

11649636

Incident

Jan 1, 2025

FIRE FIRE FIRE Information light came on just saying 12 Volt Battery. I sat in the car letting it idle for about 3 minutes. It began to smoke and then burst into flames. I called 911 got the fire department here but by the time they were here there was not much left. The car essentially burned to the ground and insurance has declared it a total loss. Car was in my driveway, was certainly a danger to me, to my house and to my neighbor's cars and house.

NHTSA ID

11629406

Incident

Dec 2, 2024

This NCU replaces the prior NCU issued on May 15, 2025, and contains additional MY 2023 and MY 2024 vehicles which are highlighted below. In our continuing efforts to ensure the proper performance of Mercedes-Benz products and to enhance the satisfaction of our customers, Mercedes-Benz USA, LLC (“MBUSA”) is extending the warranty coverage on the Diagnostic Module for Tank Leakage detection (DMTL) in certain Model Year (“MY”) vehicles listed below from the original New Vehicle Limited Warranty of 4 years/50,000 miles to 10 years/120,000 miles (vehicles certified as LEV II) and 15 years/150,000 miles (vehicles certified as LEV III), whichever occurs first, for the following condition: •Under certain circumstances, the DMTL may trigger erroneous Diagnostic Trouble Code (DTC) entries that may result in the illumination of the Check Engine Malfunction Indicator Lamp (‘MIL’).

• Always use the latest XENTRY Diagnosis software release with all available add-ons. • Make sure to follow the operation steps exactly as described in XENTRY Diagnosis! • Use a battery charger to ensure sufficient power supply of the vehicle on-board electrical system battery (greater than 12.5 V). • If XENTRY Diagnosis is already connected to the vehicle, start with operation step 2. If two or more software updates or SCN coding’s are performed during one workshop visit or SCN coding operations are performed, operation items 02-4762 and 02-5058 must only be invoiced once for each workshop order! Work Procedure: 1. Connect XENTRY Diagnosis. 2. Update engine electronics (ME) control unit software. To do so, select menu item "Quick test view → N3/10 - Engine electronics 'MED40' for combustion engine 'M274' (ME) → Adaptations → Control unit update → Update of control unit software". Then follow the user guidance in XENTRY Diagnosis. 3. Disconnect XENTRY Diagnosis.

Complaint Hand detection system – malfunction / vehicles with code 266 Fault message in instrument cluster: "Active Emergency Stop Assist not available" "Active Lane Keeping Assist not available" "Active steering assist not available" Cause Possible causes: Hand detection mat, hand detection control unit, contacts, and electrical feed line. Remedy In the event of a customer complaint and fault code in IDC control unit: U186B29 in IDC223 or fault code U0429E0, U042941, U042929, U042902, U0429E1 in IDC213 or fault code in HOSWD control unit: B1E7614 Check: Please do not replace the HOSWD control unit. Please flash the new SW and perform the SCN coding for the HOSWD control unit (N179/1) (available from July 2026). The software can be flashed onto all HOSWD213 with HW number A0009011522 and all HOSWD223 with HW number A0009011422. Please also flash the SW for the IDC control unit (N62/4), if possible (only applies to HOSWD223). Erase fault memory Remedy: Turn on the ignition or start the engine without touching the steering wheel. If, after 10 seconds without touching the steering wheel, one of the three fault messages appears on the instrument cluster: Check the contacts and feed lines in the steering wheel by means of a visual inspection for damage, crimp connections, loose connections, etc. (example in picture 2 and 3). If there is visible damage -> replace the steering wheel electronics or the feed lines. If there is not any visible damage -> replace the steering wheel rim. If a yellow message does not appear on the instrument cluster within 10 seconds: Grasp the steering wheel fully with both hands, including the chrome molding at the 6 o'clock position (see picture 1). If the fault is triggered by grasping the steering wheel rim or pressing the clip at the 6 o'clock position, check the contacts and feed lines in the steering wheel by means of a visual inspection for damage, kinked connections, loose connections, etc. (example in picture 2 and 3). Check the ground connections (screw connections and cables to the steering wheel rim); if necessary, retighten the screws/bolts and check for corrosion (picture 4). If there is visible damage -> replace the steering wheel electronics or the feed lines. If there is not any visible damage: Replace the steering wheel rim. Please do not replace the HOSWD control unit. A TIPS case should be created if fault profile is unclear. In the event of a customer complaint and a further fault code in HOSWD: B1E7713: Check the ground connections (screw connections and cables to the steering wheel rim); if necessary, retighten the screws/bolts and check for corrosion (picture 4). B1F1F04: Check the control unit of the hand detection system; if necessary, replace this with the control unit from a donor vehicle (make sure that the hardware part numbers are identical).

Single throttle lift-off clunking noise from the side shaft when moving off (audible at the outboard end). The noise is heard once in each instance when changing direction of travel. Note: Sound file in attachment Cause If the complaint is eliminated by experimentally loosening the outboard collar nut (by 1 turn), the problem is due to cracking of the microweld between the wheel bearing inner race and the joint housing of the side shaft. Note: The collar nut must always be replaced after being loosened. See also LI33.20-P-078406 Remedy Coat contact surface of side shaft with wheel bearing with Molykote paint. To do this, proceed as follows: 1. Remove side shafts 2. Clean contact surface A (see image file in attachment "Outer joint housing before") before coating with Molykote, using "spirit" (free of dust and grease) 3. Coat contact surface A (see image file in attachment "Outer joint housing after") with Molykote and leave to dry for "one hour" in removed condition 4. Reinstall side shafts Note: Before using the antifriction coating (Molykote), stir it or shake it thoroughly for (at least 1 minute).

Complaint Service code B1 displayed in the customer menu does not match the workshop code displayed in the workshop menu, e.g., 505 or 550A, which includes a service A. Cause The root cause is currently being investigated. Remedy To determine the cause, the instrument cluster control unit (N133/1) and powertrain control unit (N127) logs are required before confirming the service or correction using XENTRY Diagnosis. Please open a TIPS case to BCE inbox with the requested information in the attachments.

Complaint The customer requests deactivation of the N112/9 HERMES communication module Note: Deactivation of the HERMES control unit (N112/9) is not supported for gray-market vehicles. Cause Before deactivating the HERMES control unit (N112/9), it must be clarified by the legal department of the respective MPC whether and under what conditions deactivation may be carried out. If deactivation is not permissible under applicable law, the HERMES control unit (N112/9) must not be deactivated. Remedy Please inform the customer that, following deactivation, the vehicle will no longer be able to place an automatic emergency call, nor will the customer be able to place a manual emergency call. After deactivation, the Mercedes-Benz Digital Extras will also no longer be available. Please have the attached sample form checked by your market's legal department, adapted to local requirements if necessary, and approved. Furthermore, after informing the customer about the effects of deactivation, please have the workshop complete and sign the approved form together with the customer, and send it to the MPC via a TIPS case for audit-compliant documentation. Furthermore, the workshop must affix a sticker to the emergency call button cover on the overhead control panel and to the emergency call button itself. After affixing, pictures of the overhead control panel need to be attached to the TIPS case for audit-proof documentation. After deactivation, the HERMES control unit (N112/9) is in the "Out of Service" operating status, and the display "SOS NOT READY" appears in the Audio/COMAND system. This display message tells the customer that the emergency call function is not available. In detail, the following steps must be carried out 1. The workshop must inform the customer about the effects of deactivation (see above) 2. Legal review by the MPC Legal department to determine whether deactivation is permissible for the vehicle and provision of a market-specific customer form based on the examples (see "Example - Deactivation communication module HERMES customer declaration English V3.0.pdf") 3. Completion of the market-specific customer form by the workshop and obtaining the customer’s signature 4. Creation of a XSS ticket by the workshop for the MPC with the signed customer form attached 5. Written confirmation of legally reviewed and approved deactivation by the MPC in the TIPS case (see attachment How+to+request+adding+Code+09o+via+XSS+v2.pdf, point 1) 6. Creation of an XSS ticket for documentation of the SA code "09o" (zero nine oh) in the Vehicle Documentation System (see attachment How+to+request+adding+Code+09o+via+XSS+v2.pdf, steps 2–7) 7. Ordering of stickers (part number A9078172900), quantity: 2 8. Affixing of the sticker (part number A9078172900) to the cover of the emergency call button on the overhead control panel (see attachment HERMES-Deactivation_+pictures+of+sticker.png) 9. Affixing of the sticker (part number A9078172900) to the emergency call button on the overhead control panel (see attachment HERMES-Deactivation_+pictures+of+sticker.png) 10. Taking photos of the applied stickers and attaching them to the TIPS case 11. After the XSS ticket has been successfully processed, the communication module must be deactivated using XENTRY: • Connect XENTRY Diagnosis • Access the HERMES control unit (N112/9) • "Adaptation" tab, menu item "Teach-in processes" -> "Deactivation" • Follow the instructions