2021 Mercedes-Benz E350

Engine misfires, lower engine power, and a lit check engine/Malfunction Indicator Lamp. Mercedes-Benz issued an Emission Service Campaign (No. 2021070006, internal code 21P1590208) to replace out-of-spec ignition coils on 657 vehicles from model year 2021, including the E-Class. My VIN was not included in the recall campaign but my vehicle is experiencing these exact symptoms as referenced in the first sentence. My vehicle has 48,000 miles.

NHTSA ID

11755689

Incident

Aug 4, 2026

Vehicle: 2021 Mercedes-Benz E350 Sedan (W213) VIN: [XXX] While operating the vehicle, the diagnostic system displayed the fault code P240200 related to the Evaporative Emission Control System (EVAP). The warning message indicated a “positive short circuit” in the fuel vapor leak diagnosis pump control circuit. The malfunction appears to involve the EVAP diagnostic module and/or associated electrical wiring near the fuel system. The affected component may be available for inspection upon request. The issue raises safety concerns because the fault involves an electrical short circuit associated with the fuel vapor control system. Potential risks may include electrical overheating, malfunction of the fuel vapor management system, fuel vapor leakage, emissions-related failures, or unexpected vehicle operating issues. Prior to the incident, warning messages appeared on the vehicle diagnostic display. The fault code was identified using the vehicle’s onboard diagnostic system. No collision or fire occurred at this time. The problem has not yet been fully repaired, but preliminary assessment suggests a possible failure of the EVAP leak detection pump, control module, wiring harness, connector, or related electrical components. The condition may be reproducible because the warning message remains active. The vehicle has not yet been inspected by the manufacturer or insurance representatives. Dealer inspection is planned. UNKNOWN whether this condition is currently associated with an official recall or service campaign for this VIN. This vehicle was originally purchased in the United States and is currently located outside the [XXX] . INFORMATION REDACTED PURSUANT TO THE FREEDOM OF INFORMATION ACT (FOIA), 5 U.S.C. 552(B)(6)

NHTSA ID

11736678

Incident

May 2, 2026

With the car only have about 15,000 miles the transmission has failed . I have seen there have been recalls of other models with similar complaints of transmission failure .

NHTSA ID

11708688

Incident

Dec 25, 2025

Engine keeps having a misfire that Mercedes put a TSB out for and once the misfire happen I cause the vehicle to go in a limp mode which causes the vehicle to loose power happened to me in the freeway. The car had 54K miles and Mercedes refused to repair the issue as the engine part failure isn’t common.

NHTSA ID

11707258

Incident

Dec 2, 2025

My 2021 Mercedes-Benz E350 (VIN [XXX] ) developed a serious engine issue involving cylinder misfire and check engine light. The dealer diagnosed it as a leaking exhaust valve on cylinder 4, related to TSB LI01.30-P-072328, which documents valve seat wear in M260 engines. This is a known defect acknowledged by Mercedes in technical bulletins, and other customers in the U.S. have received warranty extensions or goodwill coverage. I was denied coverage even though this is a manufacturer defect that can lead to misfire, power loss, and potential stalling, posing a safety risk on the road. Mercedes-Benz USA refuses to cover the repair (~$7,600+), even though it relates to a factory-documented problem. I’m requesting that NHTSA investigate this engine defect, as it may qualify for a safety recall or mandatory extended warranty coverage. INFORMATION REDACTED PURSUANT TO THE FREEDOM OF INFORMATION ACT (FOIA), 5 U.S.C. 552(B)(6)

NHTSA ID

11673376

Incident

Jul 1, 2025

The Mercedes E350, with 22,000 miles suffered a catastrophic transmission failure while driving on the highway. I managed to exit the highway but the car could not be moved and left me stranded.

NHTSA ID

11672435

Incident

Jul 9, 2025

1) Rear view camera sometimes working, some times not working. (Message reads “system inoperative “ 2) Forward view camera also affected. 3) display shown “12V battery low in battery “ 4) Not long ago, just had vehicle suddenly vibrating vigorously while backing up from parking and during driving. Gas paddle not responding when stepping down, ( vehicle was then towed to dealer and they updated some kind of electrical thing)

NHTSA ID

11649636

Incident

Jan 1, 2025

FIRE FIRE FIRE Information light came on just saying 12 Volt Battery. I sat in the car letting it idle for about 3 minutes. It began to smoke and then burst into flames. I called 911 got the fire department here but by the time they were here there was not much left. The car essentially burned to the ground and insurance has declared it a total loss. Car was in my driveway, was certainly a danger to me, to my house and to my neighbor's cars and house.

NHTSA ID

11629406

Incident

Dec 2, 2024

Complaint During part of the steering movement, it feels heavier or more difficult to steer in the same spot every time. OR Rattling, humming, dry sliding/gravel noise from the electric steering system when steering (see attachment). Complaint does not impact the ability to safely steer or control the vehicle. Cause Ball screw drive (KGT) of electric steering damaged by: 1. External force due to: ‑ Hitting the curb/posts with the front wheels. ‑ Driving over obstacles (e.g. pothole/ threshold/ speed bump/ gully) at an inappropriate speed. 2. Corrosion/ water ingress through a damaged boot (see attachment). ‑ Cracks (1) ‑ High pressure cleaner (2) ‑ Animal bite (3) See various examples listed in the attachments for examples of outside influence. Remedy Remove boot clamps closest to steering gear housing on both left and right (as seen in "Steering Rack Boot Clamp Location"). Pull back boot and inspect for rust, broken end stops, water, or any other anomalies. Replace electric steering. Note: Steering gears replaced due to outside influence or damage must not be claimed under warranty!

Complaint Tailgate opens unintentionally. Cause Accidental or unnoticed activation of the button to open the tailgate on the vehicle key. EXAMPLE: when stored in trouser pocket, handbag etc. Remedy As of the 6th generation, the vehicle key can be recoded so that the tailgate no longer opens as a result of a long press on the button, but by double‑clicking on the button instead. This reduces the likelihood of the button being activated accidentally or unintentionally. The recoding can be carried out as follows: 1. Add SA Code O19 into VeDoc (O for Oscar, not "zero") • an XSS ticket may be necessary to add the SA code 2. Perform SCN coding of EIS N73 control unit 3. Deactivate the vehicle key (a successful deactivation is indicated by the LED lighting up 2x briefly and then 1x for a long period). 4. Place the vehicle key in the storage compartment on the key symbol and turn on the ignition. IMPORTANT: all other vehicle keys must be outside the recognition range of the vehicle when doing this! Perform steps 3 and 4 successively for all vehicle keys. Notes: 6th, 7th and 8th generation keys can be deactivated as follows: Up to modification year 22/1 by double clicking the "Lock button" As of modification year 22/1, by press and holding the “Lock button", then double‑click the “Unlock button" at the same time. On model series 167, the storage compartment with the key symbol is located in the armrest. The SCN coding from the EZS is only transferred correctly to the vehicle key under the following conditions: Only one vehicle key is located in the vehicle, this key has been deactivated and it is positioned on the marking in the storage compartment for the data transfer. The costs for this adaptation are to be borne by the customer. For the newer BR 174, 178, 244, 248, 520, and 540, a software update must be initiated, as there is no way to perform SCN coding.

Dear Mercedes-Benz Owner: In our continuing efforts to ensure the proper performance of Mercedes-Benz products and to enhance the satisfaction of our customers, Mercedes-Benz USA is extending the warranty coverage for the Diagnostic Module for Tank Leakage Detection ("DMTL") on your vehicle from the original New Vehicle Limited Warranty of 4 years / 50,000 miles to 15 years/150,000 miles (whichever occurs first). This applies to the vehicle regardless of ownership. Why the Warranty extension? On certain Model Year 2018 - 2024 A / C / CLA / CLS / E / G / GLA / GLB / GLC / GLE / GLS / GT / S / SL Mercedes-Benz vehicles, under certain circumstances, the DMTL may trigger erroneous Diagnostic Trouble Code ("DTC") entries that may result in the illumination of the Check Engine Malfunction Indicator Lamp ("MIL"). Any repairs under this warranty extension must be performed by an authorized Mercedes-Benz dealership. • If your preferred authorized Mercedes-Benz dealership performs a diagnosis and confirms that your vehicle has the issue, the repair will be covered under this extended warranty and performed at no cost to you. • This extended warranty does not apply to any other components or conditions beyond the ones mentioned above, and standard warranty terms apply, including the exclusions with respect to extra expenses, as identified in the Service and Warranty Information booklet.

Complaint Clanking noise from the area of the speakers in the doors. Cause Under analysis. Remedy To narrow down the cause, first of all remove the door trim. • If the noise continues to occur even with the door trim removed, then continue the diagnosis working towards the speaker and if necessary, create a TIPS case with an informative video as an attachment. Information: Please refer to this document in the warranty claim and, after completing diagnosis, select the damage code corresponding to the component part that caused the problem. • If the noise stops when the door trim is removed, please proceed in accordance with LI72.10-P-067691. Information: In this case, do not use a damage code for the speakers in the warranty claim!

Complaint A popup is seen on the HU with the message "data connection temporarily not available". Potentially affected functionalities in NTG4.5, NTG5 1.Weather 2.Local Search 3.IP Radio 4.Send2Car 5.Speech Detection Service 6.Navigation 7.iHeartRadio 8.Traffic Cams Cause MB Apps is sundowned for all vehicles with NTG4.5 and NTG5 Head Unit Variant. Remedy No support available for NTG4.5 and NTG5 Head Unit Variants for MB App related topics. Note: Please do not create TIPS. Please do not replace any components. HU/Hermes SW update / SCN coding will not fix the issue.

Complaint This document is intended as a pre-case diagnostic reference for transmission related concerns. It will also ensure that if a case is necessary, all supporting documentation is available. This should not be used on its own as justification for creating a TIPS case. Cause The root cause will vary depending on the complaint. The goal of this document is to provide diagnostic checks and procedures that may help resolve customer complaints without opening a TIPS case. Remedy Before opening a transmission-related TIPS case, the following steps must be performed to ensure all relevant data has been collected and possible remedies (when applicable) have been performed. Please Note: At minimum, the documents below must be collected before proceeding to ensure the data in its original state when the vehicle arrived is captured. - Initial Quick Test w/ Freeze frame data - VGS Control Unit Log - Initial EEPROM data (.txt format) - IPR Result (if applicable. See LI27.00-P-073124 - Transmission diagnosis using the Intelligent Predictive Repair (IPR) tool) - Transmission Heath Page If the vehicle has previously been repaired for the same concern, note the date, mileage, and TIPS case or RO number, along with a brief description of the prior work performed. IPR Guidance: The IPR recommended repair should be completed prior to following any steps in this LI and prior to case creation. IPR repairs do not require additional warranty approvals or a TIPS case to validate/confirm the results. To ensure efficient case handling, please avoid opening TIPS cases for this reason. For further information regarding IPR please see the following documents: LI27.00-P-073124 - Transmission diagnosis using the Intelligent Predictive Repair (IPR) tool Oil Pan Condition Evaluation: In some situations, IPR will advise checking the oil pan condition and determining a repair based on the evaluation. Example photos in Xentry can be found in two ways: • Use the blue hyperlink in the IPR result, and it will take you to the Condition check of transmission oil • Navigate to Xentry Bluebook > Help for control unit > Condition check of transmission oil If a different repair that what is recommended by IPR is performed, attaching photo documentation of the complaint vehicle oil pan and the IPR example to the claim is required. Reproducing the Concern: Proper evaluation of transmission concerns generally requires the condition to be reproducible. It is recommended to compare the vehicle to a similar model, if available, to help determine whether the shift behavior is characteristic of the drivetrain or uncharacteristic for the vehicle. If the concern cannot be duplicated: • A test drive with the customer may assist in understanding and reproducing the complaint. • The vehicle shift quality should be compared to a known-good vehicle with identical drivetrain and model year. • Check Shift Quality History (VGS Control Unit > Adaptations > Shift Quality History) Shift Quality History will show the last 5 noticeable harsh shifts and some of the parameters in which it occurred. You can use this to attempt recreation of the operating conditions and increase likelihood of reproducing the complaint. Complaint A: Shift Quality Note: Certain AMG variants may exhibit more firm and noticeable shift behavior as a normal characteristic. Refer to LI27.60‑P‑075147 for additional information. 1. Perform Valve flushing procedure 2. Perform 5 Torque Converter adaptions in a row - Allow the vehicle to warm up naturally, DO NOT power brake as it will increase the temperature in the torque converter. - After the 5th adaptation, collect a screen shot showing all 5 on one page 3. Perform a standstill adaption - collect a screen shot Recheck vehicle operation. If the concern has not improved, driving adaptations should be performed to target specific gear shifts.