2021 Mercedes-Benz E350

Engine misfires, lower engine power, and a lit check engine/Malfunction Indicator Lamp. Mercedes-Benz issued an Emission Service Campaign (No. 2021070006, internal code 21P1590208) to replace out-of-spec ignition coils on 657 vehicles from model year 2021, including the E-Class. My VIN was not included in the recall campaign but my vehicle is experiencing these exact symptoms as referenced in the first sentence. My vehicle has 48,000 miles.

NHTSA ID

11755689

Incident

Aug 4, 2026

Vehicle: 2021 Mercedes-Benz E350 Sedan (W213) VIN: [XXX] While operating the vehicle, the diagnostic system displayed the fault code P240200 related to the Evaporative Emission Control System (EVAP). The warning message indicated a “positive short circuit” in the fuel vapor leak diagnosis pump control circuit. The malfunction appears to involve the EVAP diagnostic module and/or associated electrical wiring near the fuel system. The affected component may be available for inspection upon request. The issue raises safety concerns because the fault involves an electrical short circuit associated with the fuel vapor control system. Potential risks may include electrical overheating, malfunction of the fuel vapor management system, fuel vapor leakage, emissions-related failures, or unexpected vehicle operating issues. Prior to the incident, warning messages appeared on the vehicle diagnostic display. The fault code was identified using the vehicle’s onboard diagnostic system. No collision or fire occurred at this time. The problem has not yet been fully repaired, but preliminary assessment suggests a possible failure of the EVAP leak detection pump, control module, wiring harness, connector, or related electrical components. The condition may be reproducible because the warning message remains active. The vehicle has not yet been inspected by the manufacturer or insurance representatives. Dealer inspection is planned. UNKNOWN whether this condition is currently associated with an official recall or service campaign for this VIN. This vehicle was originally purchased in the United States and is currently located outside the [XXX] . INFORMATION REDACTED PURSUANT TO THE FREEDOM OF INFORMATION ACT (FOIA), 5 U.S.C. 552(B)(6)

NHTSA ID

11736678

Incident

May 2, 2026

With the car only have about 15,000 miles the transmission has failed . I have seen there have been recalls of other models with similar complaints of transmission failure .

NHTSA ID

11708688

Incident

Dec 25, 2025

Engine keeps having a misfire that Mercedes put a TSB out for and once the misfire happen I cause the vehicle to go in a limp mode which causes the vehicle to loose power happened to me in the freeway. The car had 54K miles and Mercedes refused to repair the issue as the engine part failure isn’t common.

NHTSA ID

11707258

Incident

Dec 2, 2025

My 2021 Mercedes-Benz E350 (VIN [XXX] ) developed a serious engine issue involving cylinder misfire and check engine light. The dealer diagnosed it as a leaking exhaust valve on cylinder 4, related to TSB LI01.30-P-072328, which documents valve seat wear in M260 engines. This is a known defect acknowledged by Mercedes in technical bulletins, and other customers in the U.S. have received warranty extensions or goodwill coverage. I was denied coverage even though this is a manufacturer defect that can lead to misfire, power loss, and potential stalling, posing a safety risk on the road. Mercedes-Benz USA refuses to cover the repair (~$7,600+), even though it relates to a factory-documented problem. I’m requesting that NHTSA investigate this engine defect, as it may qualify for a safety recall or mandatory extended warranty coverage. INFORMATION REDACTED PURSUANT TO THE FREEDOM OF INFORMATION ACT (FOIA), 5 U.S.C. 552(B)(6)

NHTSA ID

11673376

Incident

Jul 1, 2025

The Mercedes E350, with 22,000 miles suffered a catastrophic transmission failure while driving on the highway. I managed to exit the highway but the car could not be moved and left me stranded.

NHTSA ID

11672435

Incident

Jul 9, 2025

1) Rear view camera sometimes working, some times not working. (Message reads “system inoperative “ 2) Forward view camera also affected. 3) display shown “12V battery low in battery “ 4) Not long ago, just had vehicle suddenly vibrating vigorously while backing up from parking and during driving. Gas paddle not responding when stepping down, ( vehicle was then towed to dealer and they updated some kind of electrical thing)

NHTSA ID

11649636

Incident

Jan 1, 2025

FIRE FIRE FIRE Information light came on just saying 12 Volt Battery. I sat in the car letting it idle for about 3 minutes. It began to smoke and then burst into flames. I called 911 got the fire department here but by the time they were here there was not much left. The car essentially burned to the ground and insurance has declared it a total loss. Car was in my driveway, was certainly a danger to me, to my house and to my neighbor's cars and house.

NHTSA ID

11629406

Incident

Dec 2, 2024

Complaint Slight creaking noises when steering. Cause Noises may come from one or more sleeves of the horn contact plate. Remedy Remove the horn contact plate and check the sleeves for noise; see attached video. If necessary, apply lubricant to the sleeves.

Complaint Customer complaints relating to automatic transmission 725.0 (NAG3 Classic /9G‑TRONIC automatic transmission) and 725.1 (NAG3 facelift/9G‑TRONIC automatic transmission facelift) For faster, more effective and more targeted diagnosis, Intelligent Predictive Repair (IPR) has been developed and integrated into XENTRY Diagnosis. This ensures an automated diagnosis process. Cause As part of the on‑going quality monitoring process and associated quality and damaged part appraisals, a high number of ineffective repairs have been discovered. Such ineffective repairs have a negative impact on all those involved. For the customer, it means high costs and long repair times and for the dealer, it may result in the warranty claim being rejected. Remedy General note: IPR is available for: ‑ NAG3 Classic (automatic transmission 725.0) ‑ NAG3 Classic ‑ AMG sport model (AMG 43 and AMG 53 with converter, automatic transmission 725.0) ‑ NAG3 Classic ‑ Hybrid (automatic transmission 725.0) ‑ NAG3 Classic ‑ AMG 63 (automatic transmission 725.0) ‑ NAG3 MOPF ISG2 (automatic transmission 725.1) ‑ NAG3 MOPF Hybrid (automatic transmission 725.1) ‑ NAG3 MOPF AMG sport model (AMG 53/AMG 53e with ISG48V2 & converter /hybrid, automatic transmission 725.1) ‑ NAG3 MOPF AMG 43/63 with engine 139/177 (automatic transmission 725.1) Steps for the Service Advisor: Important: The more information and detail that can be given to the workshop about the complaint, then the more effective the subsequent diagnosis with IPR can be. To this end, a detailed service reception questionnaire has been provided to help the Service Advisor ask the right questions about the complaint. ‑ Ask precise details about the customer complaint and the conditions and context. ‑ Fill out the service reception questionnaire (please see WIS document: OF27.00‑P‑3000‑05A) for customer complaints in detail and forward it to the workshop. Operation steps for the workshop employee: 1. Perform quick test 2. Access the transmission control unit via XENTRY Diagnosis 3. Select "A customer complaint has been received" and carry out all subsequent operation steps (IPR diagnosis path). 4. The IPR repair instructions are displayed, Carry out the IPR repair instructions without performing any further diagnostic or repair steps. ‑ Important: The IPR repair instructions are binding and must be carried out. Differing repairs are possible; such repairs must be documented in XENTRY in free text. Please observe the information regarding the IPR diagnosis process in XENTRY. Conventional diagnosis and subsequent appropriate repairs are only permitted if IPR does not specify any repair instructions. Invoicing for the guided IPR steps: Operation item 27‑0640 and 0.1 hours Notice regarding warranty: The use of IPR in association with warranty claims is mandatory! If the IPR repair instructions are disregarded without justification, the warranty claims may be rejected and/or are subject to debit. IPR will provide a measure to repair the vehicle based on various data sources (EEPROM, fault codes, etc). Please consider the vehicle maintenance record of the vehicle. For warranty and goodwill repairs, the transmission ECU test log and/or IPR test result must be uploaded into Paperless XENTRY Diagnosis (pXD) . If repair is being determined based of oil pan condition pictures of oil pan MUST be provided to warranty as justification. ·Tamper‑proof documentation: The IPR repair instructions are stored in the control unit log. Please file this document in a tamperproof manner ‑ either in digital form or as a hard‑copy printout and also enclose a printout with the damaged part. In this regard, please comply with the country‑specific warranty requirements of the MPC/general distributor.

Complaint Repeat workshop visit for vehicle vibration while braking from 60MPH. NOTE: Although the symptom is similar to a tire or wheel vibration, it is usually readily noticeable that it is distinctly different if it happens at all times or only while braking. Cause Although the cause of the vibration is most likely due to excessive lateral runout on the rotor or hub/wheel bearing, the system as a whole needs to be checked for other possible contributors. 1. Prior collision damage. 2. Excessive vehicle sitting times without rotating components. 3. Wheel bearing/hub lateral runout. 4. Wheel mating interface has been overtightened (did not follow WIS torque procedures). 5. Mating interfaces have been excessively modified (painted, gouged, bent, etc...). Remedy Read through the entire attached worksheet prior to performing. After performing, please review the final page and perform work accordingly. NOTE: This document is not pre‑authorization or otherwise dealing with warranty. This is intended for diagnostic purposes only. If there are any questions on how to proceed OR The work sheet has been performed and the vehicle has returned with the same concern. Please perform the measurements as seen in the worksheet again and open a TIPS case to the Body, Chassis, and Entertainment team.

Complaint Red coolant warning in instrument cluster. Fault codes U019F00 or U019F87 current/stored in MRG1 control unit. Cause Various causes Remedy Perform guided test for fault code U019F with XENTRY diagnosis. Verify the following connections are clean and tight. Correct any problems and retest pump actuation: ‑12V plug at M75/11 ‑48V plug at M75/11 ‑48V connector X192/4 ‑Connections at 48V fuse box F153/2 ‑Sockets 1,2, and 5 at connector 2 of MRG1 control unit ‑M75/11 circuit 41 ground If actuation and above connections are OK, but resistance between M75/11 and engine block is less than 2 ohms or heat shield touching coolant pump, proceed with below steps. 1‑Modify engine insulation per attached instructions. 2‑Remove engine control module and measure continuity within control unit between connector 2 pin 1 and connector 6 pin 2. 2a‑If open circuit is found, replace engine control unit (MRG1) and perform initial startup. Refer to XENTRY parts information group 54/054 item 300. 3‑Clear faults and verify M75/11 operating normally.

Complaint Clanking noise from the area of the speakers in the doors. Cause Under analysis. Remedy To narrow down the cause, first of all remove the door trim. • If the noise continues to occur even with the door trim removed, then continue the diagnosis working towards the speaker and if necessary, create a TIPS case with an informative video as an attachment. Note: Please refer to this document in the warranty claim and, once diagnosis is completed, select the damage code depending on the component part that is causing the issue. • If the noise stops when the door trim is removed, please proceed in accordance with LI72.10‑P‑067691. Information: In this case, do not use a damage code for the speakers in the warranty claim!

Complaint Only vehicles with a variable transfer case are affected. This can be identified through control unit N45 or N15/7 in the quick test. When accelerating with light load, vibrations or jolting sensation may come from the drivetrain. It may be mistaken for a harsh shift. Cause Modified oil quality of the transfer case over time Remedy 1. Check initial quick test for faults in the following control units. N45 or N15/7 ‑ All‑wheel drive (ARS) N127 ‑ 'Drivetrain' (PTCU) control unit Y3/8 ‑ Transmission control for 9‑gear transmission (VGS) N3/10 ‑ Engine electronics for combustion engine If faults are present: Process them as per the guided test in Xentry. If no faults are present: 2. Check the transmission oil level If the oil level is correct: 3. Unplug the connector for the transfer cases control unit and reassess the vehicle on a subsequent test drive If the complaint no longer occurs with the control unit disconnected: 4. Perform an oil change of the transfer case according to WIS specifications ‑ Collect an oil sample of the original fluid 5. Complete all transfer case Tech‑in processes located under VG Control Unit > Adaptations ‑ Resetting the oil service data ‑ Calibration of N15/7 5. Perform road test of vehicle to bring transmission to operating temperature (>60C ) 6. Operate vehicle in full circle with steering at full lock ‑ 5x to the left ‑ 5x to the right Return the vehicle to the client and request they drive the vehicle for at least 200 miles and return if the concern is not resolved. The extended drive will ensure the clutches are properly conditioned with the new oil and should resolve the concern. If this LI has already been applied to the vehicle, please submit a TIPS case to the Powertrain inbox with the following information: ‑ Initial quick test with fault freeze frame data ‑ Initial transmission EEPROM data ‑ VGS and Transfer Case Control Unit Log (N45 or N15/7) ‑ Special Acquisition Data .txt file (Transfer Case Control Unit > Special Procedures > Procedures for support queries to market support > Special Data Acquisition) ‑ Photo of the original oil condition ‑ What color was the fluid drained from the transfer case before the oil change? ‑ Was an oil sample collected, and can you provide a photo of the original fluid? ‑ What color and part number fluid was used during the oil change? ‑ How far was the vehicle driven after?