2021 Ford E350 Owner Complaints

Engine misfire on a 2021 Ford E-350 cutaway, 7.3L V8, used for parcel delivery. The vehicle was delivered to Ford of Spartanburg (Ford dealership) for diagnosis. The vehicle is still out of service. Ford's diagnosis, Repair Order 593079, June 26, 2026: "WILL NEED TO REPLACE ALL SPARK PLUGS AND WIRES, WILL ALSO NEED TO REPLACED ALL COILS DUE TO MISFIRES ON ALMOST EVERY CYLINDER." The Ford service advisor wrote the same day: "The engine also has a misfire that is unrelated to the transmission concern." Ford quoted $4,376.35 for the ignition components and wrote: "AFTER REPAIRING TRANSMISSION WILL NEED TO DIAGNOSE ALL OTHER CONCERNS WITH VEHICLE, CANNOT DIAG ANYTHING AT MOMENT DUE TO NOT BEING ABLE TO DRIVE VEHICLE." Ford has not completed the engine diagnosis; on July 27, 2026 it advised against a compression test and offered one at $920.00. This is the second engine failure on this VIN. In January 2024 at 103,177 miles, the same Ford dealership diagnosed "Found a misfire and low compression on cylinder 3, ordered engine and replaced the engine with new intake gaskets, exhaust manifold gaskets, torque converter nuts, found the reinforcement cracked and replaced it" and installed a Ford service engine, part LC3Z-6006-B (Invoice 551352C; I paid $10,000.00). That Ford replacement engine is the one now misfiring, after at least 63,580 miles. Note on mileage: Ford's RO 593079 records 103,778 miles; Ford's own January 2024 invoice recorded 103,177 and independent records show 166,757 on January 12, 2026 and 169,140 on February 4, 2026. The Ford RO figure is not an actual reading. The same 7.3L engine has failed on nine vehicles in this fleet; NHTSA holds VOQ 11582566, 11582592, 11582598, 11582601, 11582604 and ODI 11714692, 11714694, and NHTSA ODI (Mr. J. Williams) has the complete record as of September 6, 2026. North Carolina DOJ Consumer Protection File No. 2026-180591 is open on the same matter.

NHTSA ID

11763935

Incident

Feb 13, 2026

Engine failure on a 2021 Ford E-350 cutaway, 7.3L V8, used for parcel delivery. The vehicle was taken out of service and has not run since. Two diagnoses, both in writing. ACME Mobile Service, July 27, 2026, at 152,760 miles: "Found the #5 cylinder is completely disabled and dropped out. Truck will need a new motor." Ford of Spartanburg (Ford dealership), Repair Order 595835, August 25, 2026: "FOUND ENGINE IS KNOCKING, WILL NEED TO REPLACE MOTOR." Ford quoted $16,000.82 for a long-block replacement. The engine is available for inspection. This is the second engine failure on this VIN. In March 2023 at 83,575 miles the engine was rebuilt with new Ford parts (camshaft, sixteen lifters, rocker arms, cylinder heads) after a camshaft and lifter failure. On the day the rebuild was completed the shop recorded "03/31/2023- NEW ENGINE FAILED. ENGINE STARTED KNOCKING AND HAD NOISE COMING FROM TOP END." and Ford replaced the complete engine under warranty in April 2023 (Ford claim CAS-42271539-G0F3ZF). That Ford replacement engine is the one that has now failed, after 69,185 miles. Ford's own repair order of August 25, 2026 lists Safety Recalls 20S73 and 24S07 for this VIN at $0.00, i.e. not performed, while the vehicle sat at the Ford dealership. Ford Customer Experience declined assistance on August 25, August 28 and September 9, 2026 and closed the case. The same 7.3L engine has failed on nine vehicles in this fleet; NHTSA already holds VOQ 11582566, 11582592, 11582598, 11582601, 11582604 and ODI 11714692, 11714694 on those, and NHTSA ODI (Mr. J. Williams) has the complete vehicle-by-vehicle record as of September 6, 2026. North Carolina DOJ Consumer Protection File No. 2026-180591 is open on the same matter.

NHTSA ID

11763932

Incident

Jan 6, 2026

fatal Camshaft and lifter failure requiring an engine replacement

NHTSA ID

11714692

Incident

Jul 31, 2024

Engine failure at 78,172, excess wear to the camshaft lobes and valve tappet surface. We have had 22 failures. There was a recall -24B27 for 2021 and 2022 models year for idle oil pressure. Most vans had 70 to 80k on them by the time we received a letter. Some engine have been changed twice. Ford has a serious problem and is not acknowledging it. Please help! Montachusett Regional Transit Authority , Fitchburg MA 01420

NHTSA ID

11701901

Incident

Mar 4, 2025

This is one of 4 of my 2021 ford econoline fleet vehicles purchased in 2021 that have had engine failure. I am one of many contractors in my area and others around the country who have had this issue with the same F59 engine. Ford has failed to issue a recall.

NHTSA ID

11643148

Incident

Jun 1, 2024

This is one of 4 of my 2021 ford econoline fleet vehicles purchased in 2021 that have had engine failure. I am one of many contractors in my area and others around the country who have had this issue with the same F59 engine. Ford has failed to issue a recall.

NHTSA ID

11643144

Incident

Jul 1, 2024

This is one of 4 of my 2021 ford econoline fleet vehicles purchased in 2021 that have had engine failure. I am one of many contractors in my area and others around the country who have had this issue with the same F59 engine. Ford has failed to issue a recall.

NHTSA ID

11643142

Incident

Apr 1, 2024

See attached document for complaint.

NHTSA ID

11623611

Incident

Oct 17, 2024

After hitting a very rough patch of interstate, our steering became very difficult. The driver thought that maybe we had a low tire, so looked for a place to pull over. We crested a hill, and there was an exit with a truck stop. As we attempted to slow for the exit, the driver discovered we had no brakes or power steering. Driver used the brakes on the trailer we were towing to slow us and bring us to a stop. Checked the brake fluid reservoir. It was empty. Bought more, but as soon as the pedal was pushed, it was gone. We were towed to a repair shop, and they discovered the high pressure line on the Hydroboost brake system had separated. The repair shop was able to find a replacement from Ford Motor Co., and repaired our motorhome. We had this exact component inspected 2 years ago when Ford issued an inspection report. We passed. This incident happened 2500 miles from home. When we arrived home, there was a letter from Ford (24N03) stating they were extending the "warranty" period on the high pressure line.

NHTSA ID

11609275

Incident

Jul 17, 2024

Safety recall

NHTSA ID

11605939

Incident

Aug 1, 2024

On 6/2/23, brakes failed to work when applying heavy pressure, causing a rear end collision.

NHTSA ID

11596399

Incident

Jun 2, 2023

See attached document for complaint,

NHTSA ID

11582604

Incident

Feb 23, 2024

See attached document for complaint,

NHTSA ID

11582598

Incident

Feb 23, 2024

See attached document for complaint,

NHTSA ID

11582566

Incident

Feb 23, 2024

The contact owns a 2021 Ford E-350. The stated while driving into the driveway, the vehicle made an abnormal popping sound. The vehicle lost power steering functionality, and the brake pedal became spongy. Additionally, the contact stated that there was a trail of fluid in the driveway. The contact stated that upon opening the hood, he noticed that the brake line had fractured, and brake fluid was leaking inside the engine compartment. There was no further information provided. The manufacturer was notified of the failure and referred the contact to a dealer; however, the dealer could not accommodate the vehicle. The dealer was contacted and diagnosed the vehicle at the contact's residence. The dealer determined that unknown hoses needed to be replaced and the failure was related to NHTSA Campaign Number: 22V089000 (Steering, Service Brakes, Hydraulic). The dealer and the manufacturer informed the contact that the vehicle could not be covered under the recall as the recall was previously marked as complete. The contact stated that the dealer had not completed the recall repair on the vehicle. The vehicle was not repaired. The failure mileage was approximately 40,000.

NHTSA ID

11530672

Incident

Jul 5, 2023

Mileage

40,000 mi

The contact owns a 2021 Ford E-350. The contact stated that while driving at undisclosed speeds, the power steering and brakes became inoperable. There were no warning lights illuminated. The vehicle was towed to the local dealer where it was diagnosed with loosened brake line fittings and an unknown fluid leak. The vehicle was repaired. The contact stated the failure was related to NHTSA Campaign Number: 22V013000 (Fuel System, Diesel). The manufacturer was contacted but no additional assistance was provided. The failure mileage was approximately 13,667.

NHTSA ID

11472024

Incident

Jun 20, 2022

Mileage

13,667 mi

The contact owns a 2021 Ford E-350. The contact stated that the vehicle was included in NHTSA Campaign Number: 22V089000 (Steering, Service Brakes, Hydraulic) and the vehicle was inspected. During the inspection, there were no leaks found. The contact stated while driving approximately 65 MPH after the inspection, the vehicle lost power steering functionality. The contact coasted the vehicle off the highway. The contact stated that while driving afterward and attempting to depress the brake pedal, the vehicle failed to respond as designed. The contact pulled over and had the vehicle towed to the dealer where the recall repair was completed. The manufacturer was made aware of the failure. The approximate failure mileage was 10,800.

NHTSA ID

11471820

Incident

May 27, 2022

Mileage

10,800 mi

The contact owns a 2021 Ford E-350. The contact's wife was driving into a parking lot at approximately 5 MPH when the power steering and the brakes failed. The contact's wife was able to safely stop the vehicle. The contact stated that his wife had not observed any warning lights being illuminated. The contact's wife examined the vehicle and noticed that there was red fluid puddling on the ground and a hissing sound coming from the driver’s side under the engine. The vehicle had not been towed to a dealer and had not been diagnosed or repaired. The contact researched online and related the failure to NHTSA Campaign Number: 22V089000 (Steering, Service Brakes, Hydraulic). The manufacturer had not been informed of the failure. The failure mileage was approximately 22,000. Consumer purchased the unit in Las Vegas on March 13th with 21,477 miles on the odometer and it failed on April 1st, with 22,018 miles on the odometer.

NHTSA ID

11459276

Incident

Apr 1, 2022

Mileage

22,000 mi

The vehicle was very difficult to keep on the road. It wanted to go all over the road. It was a struggle to keep it in the lane. We took the RV back to the dealer we bought it from & they told us they didn't work on that & to find a Ford dealer that would work on it. After many phone calls I found a Ford dealer that would work on it. They told us nothing was wrong with the steering. It was engineered badly. They said the back end was too heavy & was making the front end light & "squirrely" & difficult to steer. They said it needed heavier suspension on the back end. They suggested heavier springs or installing suspension air bags. The other problem was the dash board lights started flashing off & on. Most of the time the dashboard lights were off. We could only see the speedometer, gas gauge & other gauges when the lights flashed on. But we didn't know if they were accurate when they were on. At one point we smelled wires burning & then the cruise control went out. The electrical problems started 07/19/2021.

NHTSA ID

11427787

Incident

Apr 29, 2021

The contact owns a 2021 Ford E-350. The contact stated while driving 60 mph, the contact started to smell a burning odor coming from the RV. The contact attempted to pull over the RV to the side of the roadway however, the RV became difficult to steer. The contact pulled over the RV and checked underneath the RV and the front hood and noticed that power steering fluid had leaked all over the engine. The contact continued driving to his destination and then had the RV towed to an RV lot. The RV was not diagnosed nor repaired. The manufacturer was made aware of the failure. The failure mileage was approximate 5,000.

NHTSA ID

11424629

Incident

Jul 3, 2021

Mileage

5,000 mi

The contact owns a 2021 FORD E-350. The contact received notification of NHTSA Campaign Number: 20V795000 (ENGINE) however, the dealer informed the contact that only one part of the remedy, mentioned on the manufacturer's website, was available and not the other. The contact received the reprogramming (UPDATE THE POWERTRAIN CALIBRATION) mentioned on the Ford website but not the other portion of the repair mentioned on the website (INSTALL ENGINE COVER INSULATION PATCHES IN THE RIGHT HAND AND LEFT HAND INNER LOWER CORNERS OF THE ENGINE COVE). The contact stated that the failure reoccurred and that when they looked up the recall on the NHTSA website stated that there was no recall repair available at all. The contact stated that the manufacturer exceeded a reasonable amount of time for the recall repair. The manufacturer was made aware of the issue. The contact had stated that after they received the repairs regarding this matter their vehicle's engine cover still gets extremely hot. The failure mileage was unknown. Vin tool confirms parts not yet available.

NHTSA ID

11421609

Incident

Aug 1, 2020

The contact owns a 2021 Ford E-350. The contact stated while driving at various speeds in windy conditions, the “Service Advance-trac” warning message was displayed on the instrument panel. Soon after the initial message was displayed, the Traction Control, Pre-Collision Assist, Cruise Control, and the Hill Start Assist messages also all appeared on the instrument panel. The contact called and made an appointment with the local dealer however, the vehicle was not yet diagnosed nor repaired. The manufacturer had yet to be notified of the failure. The failure mileage was approximately 1,500.

NHTSA ID

11420395

Incident

Jun 8, 2021

Mileage

1,500 mi